Epilepsy is one of the common chronic diseases in neurology. In addition to primary epilepsy, traumatic brain injury, brain tumor, cerebrovascular disease, etc. can cause secondary epilepsy. The incidence of epilepsy is second only to cerebrovascular disease in neurology. In addition, due to the unpredictable nature of epileptic seizures, there are at least hundreds of millions of potential populations with active epilepsy.
Epilepsy has a great impact on the patient’s body, spirit, mind, life, work, family, and other aspects. At present, the treatment of epilepsy is mainly based on drugs, but its limitations are quite large, and it is easy to develop drug resistance or cause serious adverse reactions. In addition, about 30% of patients are insensitive to anti-epileptic drugs and require expensive and invasive treatments such as surgical resection and deep brain stimulation. Therefore, it is of great significance to explore new anti-epileptic methods.
Transcranial magnetic stimulation (TMS) acts on the cerebral cortex through a time-varying magnetic field to generate inductive currents and affect the electrical activity of cells, thereby exerting a neuromodulation effect. As a non-invasive diagnosis and treatment method, TMS has attracted the attention of clinicians and researchers, and is increasingly used in epilepsy-related basic research and clinical diagnosis and treatment, and has an encouraging application prospect. Therefore, TMS is a potential epilepsy diagnosis and treatment method, which is worthy of further exploration.
Transcranial Magnetic Relevant Safety Studies
88 patients with epilepsy were divided into a drug treatment group and a transcranial magnetic stimulation combined drug group according to the random number table method, with 44 cases in each. The drug treatment group was treated with first-line antiepileptic drugs, while the transcranial magnetic stimulation combined with the drug group was treated with first-line antiepileptic drugs plus transcranial magnetic stimulation. The treatment effects were compared between the two groups; seizure frequency, Hamilton Depression Scale-17 score; quality of life score before and after treatment; the time when the number of seizures was reduced by 50%, the time when the time of seizures was reduced by 50%, and the occurrence of adverse reactions.
Clinical drug treatment of epilepsy is effective, first-line antiepileptic drugs can improve epilepsy symptoms, control epilepsy, and have a good therapeutic effect on epilepsy patients, but most patients can still relapse after receiving drug treatment, and long-term medication is required, and adverse reactions are prone to occur. , Need to explore more effective and safe treatment options to improve the quality of life of patients.
Transcranial magnetic stimulation therapy can change the excitability of the resting cortex by changing the risk of cerebral cortex in patients with epilepsy, stimulating the corresponding parts of the cerebral cortex, changing the functional activity of neurons, and affecting the transmission of excitability, thereby regulating the thalamus and basal section and other functions. Transcranial magnetic stimulation reduces neuronal excitability by inhibiting the release of the neurotransmitter γ-aminobutyric acid, thereby inhibiting the function of the ascending reticular excitation system in the brainstem, and improving sleep quality, depression and epilepsy.
Studies have shown that transcranial magnetic stimulation can regulate the excitability of the cerebral cortex, deeply stimulate the brain, which is easy to operate, maintains the balance between the excitability and inhibition of cortical neurons, regulates the activity of nerve cells, and effectively controls their excitation. and inhibited state.
In conclusion, the first-line antiepileptic drugs combined with transcranial magnetic stimulation are effective in the treatment of epilepsy, which can effectively control epileptic seizures, improve the quality of life of patients, reduce the depression of patients, and have no obvious adverse reactions.
How to control epilepsy seizures?
1. Stay in a good mood
2. Get enough sleep
3. Scientific and reasonable diet
4. Do a good job of keeping warm
5. Take medication regularly